Study of the Risk and Preventive Factors for Progress of Mild Cognitive Impairment to Dementia

Abstract

Objective: To evaluate the risk factors for progress of mild cognitive impairment to dementia. Methods: This study was based on the epidemiological survey in 2011 (No. PKJ2010-Y26) and contained 441 MCI individuals. Cognitive function was measured by the Mini-Mental Status Examination, clinical dementia rating, and montreal cognitive assessment. The association between demographic characteristics and MCI outcomes were evaluated using single-and multifactor ordered logistic regression analysis models. Results: Of the 441 MCI, 77 progressed to dementia (MCIp: 17.5%, 95% CI: 14.4%-21.6%), 356 remained stable (MCIs: 80.7%, 95% CI: 77.0%-88.4%), and 8 reverted to normal cognition (MCIr: 1.8%, 95% CI: 0.6%-3.0%) at follow-up in 2017. Univariate ordinal regression analysis showed that diabetes ( P = .052), marriage ( P = .028), worker ( P = .069), and manager ( P = .075) may be the risk factor for the status of MCI. Multiple ordinal regression results showed that diabetes ( P = .049) and marriage ( P = .04) significantly affected the cognitive function changes in the MCI patients. Conclusion: Nondiabetics and being married may prevent the progression from MCI to dementia.