Extrapyramidal Signs in the Primary Progressive Aphasias-Reference-Cited by-同舟云学术

Extrapyramidal Signs in the Primary Progressive Aphasias

Published:2011-01-31 Issue:1 Volume:26 Page:72-77
ISSN:1533-3175
Container-title:American Journal of Alzheimer's Disease & Other Dementiasr
language:en
Short-container-title:Am J Alzheimers Dis Other Demen

Author:

Kremen Sarah A.¹,Mendez Mario F.²,Tsai Po-Heng²,Teng Edmond³

Affiliation:

1. Neurobehavior Unit, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA, Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA,

2. Neurobehavior Unit, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA, Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA

3. Neurobehavior Unit, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA, Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA, Geriatric Research Education and Clinical Center, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA

Abstract

Background: Extrapyramidal signs (EPS) may vary across 3 major subtypes of primary progressive aphasia (PPA): progressive nonfluent aphasia (PNFA), semantic dementia (SD), and progressive logopenic aphasia (PLA). Methods: We reviewed initial neurological examinations from a clinical PPA cohort (PNFA = 49, SD = 26, PLA = 28) to determine the prevalence of specific categories of EPS. Results: The presence of any EPS was more common in PNFA (38.8%) and PLA (35.7%) than in SD (3.8%). The PNFA group exhibited the highest prevalence of bradykinesia (PNFA: 22.4%, SD: 3.8%, PLA: 0.0%) and rigidity (PNFA: 30.6%, SD: 0.0%, PLA: 10.7%). Calculated positive likelihood ratios indicated bradykinesia (12.1) or rigidity (5.5) was more strongly associated with PNFA than other PPAs. Conclusion: These findings suggest that on initial presentation, specific EPS may help distinguish PPA subtypes when linguistic and/or neuroimaging profiles are indistinct. Moreover, EPS could represent a marker of underlying tauopathy, linking clinical presentation to neuropathology in PPA.

Publisher

SAGE Publications

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Neuroscience

Link

http://journals.sagepub.com/doi/pdf/10.1177/1533317510391239

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