Increased Risk of Dementia Among Patients With Pulmonary Tuberculosis-Reference-Cited by-同舟云学术

Increased Risk of Dementia Among Patients With Pulmonary Tuberculosis

Published:2015-03-18 Issue:6 Volume:30 Page:629-634
ISSN:1533-3175
Container-title:American Journal of Alzheimer's Disease & Other Dementiasr
language:en
Short-container-title:Am J Alzheimers Dis Other Demen

Author:

Peng Yi-Hao¹²,Chen Chih-Yu³,Su Ching-Hua⁴,Muo Chih-Hsin⁵,Chen Kuan-Fei⁶⁷,Liao Wei-Chih²³,Kao Chia-Hung⁸⁹

Affiliation:

1. Department of Respiratory Therapy, China Medical University Hospital, Taichung, Taiwan

2. Department of Respiratory Therapy, China Medical University, Taichung, Taiwan

3. Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, China Medical University Hospital, Taichung, Taiwan

4. Section of Respiratory Therapy, Taichung Hospital, Ministry of Health and Welfare, Taichung, Taiwan

5. Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan

6. Department of Neurology, China Medical University Hospital, Taichung, Taiwan

7. Department of Neurology, China Medical University Beigang Hospital, Yunlin, Taiwan

8. Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan

9. Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan

Abstract

Objective: We investigated and compared the risk of dementia development in a cohort of patients with tuberculosis (TB). Methods: The study involved 6473 patient with newly diagnosed TB, and each patient was randomly frequency matched with 4 people without TB based on age, sex, and index year. The risk of dementia development was analyzed using Cox proportional hazards regression. Results: Among the patients with TB, the overall risk of developing dementia was 1.21-fold significantly higher than the non-TB cohort. In the stratified analysis of dementia risks, only the patients with TB who were male or 50 to 64 years of age exhibited a significantly higher risk of dementia development compared with those without TB. An analysis of the follow-up duration revealed that patients with TB had a 1.78-fold increased risk within 1 year of follow-up. Conclusion: Patients with TB have a significantly higher risk of developing dementia than that of the general population.

Publisher

SAGE Publications

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Neuroscience

Link

http://journals.sagepub.com/doi/pdf/10.1177/1533317515577186

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