Computerized cognitive testing battery identifies mild cognitive impairment and mild dementia even in the presence of depressive symptoms

Author:

Doniger Glen M.1,Dwolatzky Tzvi2,Zucker David M.3,Chertkow Howard4,Crystal Howard5,Schweiger Avraham6,Simon Ely S.1

Affiliation:

1. Department of Clinical Science, NeuroTrax Corporation, New York, New York

2. Memory Disorders Clinic and Department of Geriatrics, Shaare Zedek Medical Center and The Ramat Tamir Home for the Aged, Jerusalem, Israel

3. Department of Statistics, Hebrew University, Jerusalem, Israel

4. Department of Clinical Neurosciences, McGill University, Montreal, Quebec, Canada

5. Department of Neurology, SUNY Downstate Medical Center, Brooklyn, New York

6. Department of Behavioral Sciences, Academic College of Tel Aviv, Tel Aviv, Israel

Abstract

Cognitive and depressive symptoms co-occur, complicating detection of mild cognitive impairment (MCI) and early dementia. In this study, discriminant validity of a novel computerized cognitive battery for MCI detection was evaluated after covariation for depressive symptom severity. In addition to the computerized battery, participants at two sites received the 30-item self-administered Geriatric Depression Scale (GDS; n = 72); those at two other centers received the observer-administered Cornell Scale for Depression in Dementia (CSDD; n = 88). In both cohorts, a Global Cognitive Score and memory, executive function, visual spatial, and verbal index scores discriminated among cognitively healthy, MCI, and mild dementia groups after covariation for GDS or CSDD, respectively (p < 0.05). Thus, the computerized battery for detection of mild impairment is robust to comorbid depressive symptoms, supporting its clinical utility in identifying neurodegenerative disease even in elderly with depression.

Publisher

SAGE Publications

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Neuroscience

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