Brain Metabolic Dysfunction in Capgras Delusion During Alzheimer’s Disease

Author:

Jedidi H.12,Daury N.3,Capa R.3,Bahri M. A.1,Collette F.13,Feyers D.1,Bastin C.12,Maquet P.1,Salmon E.12

Affiliation:

1. Université de Liège, Centre de Recherches du Cyclotron, Liège, Belgium

2. Département des sciences cliniques, Neuroimagerie des troubles de la mémoire et de la revalidation cognitive, Université de Liège, Liège, Belgium

3. Département de Psychologie: cognition et comportement, Université de Liège, Liège, Belgium

Abstract

Capgras delusion is characterized by the misidentification of people and by the delusional belief that the misidentified persons have been replaced by impostors, generally perceived as persecutors. Since little is known regarding the neural correlates of Capgras syndrome, the cerebral metabolic pattern of a patient with probable Alzheimer’s disease (AD) and Capgras syndrome was compared with those of 24-healthy elderly participants and 26 patients with AD without delusional syndrome. Comparing the healthy group with the AD group, the patient with AD had significant hypometabolism in frontal and posterior midline structures. In the light of current neural models of face perception, our patients with Capgras syndrome may be related to impaired recognition of a familiar face, subserved by the posterior cingulate/precuneus cortex, and impaired reflection about personally relevant knowledge related to a face, subserved by the dorsomedial prefrontal cortex.

Publisher

SAGE Publications

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Neuroscience

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