Affiliation:
1. Departments of Ophthalmology and Pathology, St. Louis University Eye Institute, St. Louis University School of Medicine.
Abstract
Background Malignant melanoma of the uveal tract is a rare malignancy but a significant cause of mortality and visual loss. Approximately 50% of patients diagnosed with a melanoma of the choroid or ciliary body will die of the disease within 15 years of enucleation. Methods The author reviewed the current literature on the clinical findings, epidemiology, and treatment of uveal melanoma. Results Methods of diagnosis have improved substantially in the past several years, although clinical diagnosis by an experienced examiner remains the standard in eyes with clear media. Ultrasound is the most useful adjunctive technique. While enucleation has been the mainstay of therapeutic intervention, alternative therapies – especially different types of irradiation – offer hope for tumor control and vision preservation. The Collaborative Ocular Melanoma Study, a multicenter national trial, is designed to provide long-term data on the natural history as well as therapeutic intervention. Conclusions Malignant melanoma of the uveal tract can be diagnosed clinically with more confidence than ever before. It is also possible in many cases to retain the eye and functional vision while controlling the tumor. However, unanswered questions remain about the natural history and optimal therapy of uveal melanoma.
Subject
Oncology,Hematology,General Medicine
Cited by
10 articles.
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