Affiliation:
1. Department of Pediatrics, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, People’s Republic of China
2. Guangdong Provincial Key Laboratory of Malignant Tumour Epigenetics and Gene Regulation, Guangzhou, People’s Republic of China
Abstract
Zinc finger protein 384 ( ZNF384) encodes a C2H2-type zinc finger protein that can function as a transcription factor. ZNF384 rearrangement in acute lymphoblastic leukemia (ALL) was first reported in 2002. More than 19 different ZNF384 fusion partners have been detected in ALL. These include E1A-binding protein P300 ( EP300), CREB-binding protein ( CREBBP), transcription factor 3 ( TCF3), TATA-box binding protein associated factor 15 ( TAF15), Ewing sarcoma breakpoint region 1 gene ( EWSR1), AT-rich interactive domain-containing protein 1B ( ARID1B), SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4 ( SMARCA4), SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 2 ( SMARCA2), synergin gamma ( SYNRG), clathrin heavy chain ( CLTC), bone morphogenic protein 2-inducible kinase ( BMP2K), Nipped-B-like protein ( NIPBL), A Kinase Anchoring Protein 8 ( AKAP8), Chromosome 11 Open Reading Frame 74 ( C11orf74), DEAD-Box Helicase 42 ( DDX42), ATP Synthase F1 Subunit Gamma ( ATP2C1), Euchromatic Histone Lysine Methyltransferase 1 ( EHMT1), Testic Expressed 41 ( TEX41), etc. Patients diagnosed with ALL harboring ZNF384 rearrangements commonly had a good prognosis. The mechanisms, performance, and features of different ZNF384 rearrangements in acute lymphoblastic leukemia have been well evaluated.
Funder
National Natural Science Foundation of China
Guangzhou Science and Technology Program key projects
Subject
Oncology,Hematology,General Medicine
Cited by
5 articles.
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