The Mainz Classification of Renal Cell Tumors

Abstract

Background Tumors arising from the renal tubular epithelium have variable characteristics and have been subject to a variety of histologic classifications. Methods The authors describe the distinct clinical, pathologic, phenotypic, and genotypic features of different types of renal tumors. Results The Mainz classification is now widely accepted because characteristic genetic alterations have been demonstrated in each tumor type. Conclusions The increasing emphasis on utilizing genetic characteristics of specific tumors is reflected by the more widespread use of the Mainz classification for renal cell tumors.