Research Advances in the Roles of N6-Methyladenosine Modification in Ovarian Cancer

Author:

Zhang Yuhong123ORCID,Ling Yufeng4,Zhou Ying123,Shi Xiu1,Shen Fangrong1,Zhou Jinhua1,Chen Youguo1,Yang Fan56,Gu Yanzheng3,Wang Juan1

Affiliation:

1. Department of Obstetrics and Gynecology, The First Affiliated Hospital of Soochow University, Suzhou, China

2. Clinical Research Center of Obstetrics and Gynecology, Jiangsu Key Laboratory of Clinical Immunology of Soochow University, Suzhou, China

3. Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China

4. Affiliated Hospital of Medical School, Nanjing University, Nanjing Stomatological Hospital, Nanjing, China

5. Department of Gynecology and Obstetrics, West China Second Hospital, University of Sichuan, Chengdu, China

6. Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, University of Sichuan, Chengdu, China

Abstract

Ovarian cancer (OC) is the most lethal gynecological tumor, characterized by its insidious and frequently recurring metastatic progression. Owing to limited early screening methods, over 70% of OC cases are diagnosed at advanced stages, typically stage III or IV. Recently, N6-methyladenosine (m6A) modification has emerged as a hotspot of epigenetic research, representing a significant endogenous RNA modification in higher eukaryotes. Numerous studies have reported that m6A-related regulatory factors play pivotal roles in tumor development through diverse mechanisms. Moreover, recent studies have indicated the aberrant expression of multiple regulatory factors in OC. Therefore, this paper comprehensively reviews research advancements concerning m6A in OC, aiming to elucidate the regulatory mechanism of m6A-associated regulators on pivotal aspects, such as proliferation, invasion, metastasis, and drug resistance, in OC. Furthermore, it discusses the potential of m6A-associated regulators as early diagnostic markers and therapeutic targets, thus contributing to the diagnosis and treatment of OC.

Funder

The Fundamental Research Funds for Soochow University

Project of Suzhou Science and Technology Development Plan

Project of Jiangsu Health Development Research Center

Publisher

SAGE Publications

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