Florida-California Cancer Research, Education and Engagement (CaRE2) Health Equity Center: Structure, Innovations, and Initial Outcomes

Author:

Reams R. Renee1,Odedina Folakemi T.2,Carpten John D.3,Redda Kinfe1,Stern Mariana C.4,Krieger Janice L.5,Aparicio Jose6,Hensel Brooke7ORCID,Askins Nissa8,Abreu Andre9,Adams Angela10,Agyare Edward1,Ali Jamel111,Allen John M.12,Aló Richard13,Baezconde-Garbanati Lourdes4,Brant Jason14,Brown Clyde P.1,Buxbaum Sarah G.1,Cohen Pinchas15,Cozen Wendy16,Ezenwa Miriam O.7,Falzarano Sara17,Fillingim Roger B.18,Flores-Rozas Hernan1,Fredenburg Kristianna M.17,George Thomas19ORCID,Han Bo20,Huang Yong21,Hughes Halbert Chanita4,Kiros Gebre-Egziabher1,Lamango Nazarius S.1,Lee Ji-Hyun14,Lyon Debra E.7,Mitchell Duane A.22,Mochona Bereket23,Nieva Jorge J.24,Offringa Ite A.2025,Okunieff Paul26,Parker Alexander27,Rhie Suhn K.25,Richey Joyce M.28,Rogers Sherise C.19,Salhia Bodour3,Schmittgen Thomas D.10,Segal Richard29,Setiawan Veronica W.24,Smith Ukamaka1,Su Li-Ming30,Suther Sandra1,Trevino Jose31,Velazquez-Villarreal Enrique I.3ORCID,Webb Fern J.32,Wu Anna H.3,Yao Yingwei7,Wilkie Diana J.7

Affiliation:

1. College of Pharmacy and Pharmaceutical Sciences, Institute of Public Health, Florida Agricultural and Mechanical University, Tallahassee, FL, USA

2. Mayo Clinic Comprehensive Cancer Center, Jacksonville, FL, USA

3. Department of Translational Genomics, University of Southern California, Los Angeles, CA, USA

4. Departments of Population and Public Health Sciences, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA

5. Department of Advertising, University of Florida, Gainesville, FL, USA

6. Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA

7. Department of Behavioral Nursing Science, University of Florida, Gainesville, FL, USA

8. Florida State University College of Medicine, Tallahassee, FL, USA

9. Department of Urology, University of Southern California, Los Angeles, CA, USA

10. Department of Pharmaceutics, University of Florida, Gainesville, FL, USA

11. Department of Chemical and Biomedical Engineering, Florida State University, Tallahassee, FL, USA

12. Department of Pharmacotherapy & Translational Research, University of Florida, Orlando, FL, USA

13. College of Science and Technology, Florida Agricultural and Mechanical University, Tallahassee, FL, USA

14. Department of Biostatistics, University of Florida, Gainesville, FL, USA

15. University of Southern California Leonard Davis School of Gerontology, Los Angeles, CA, USA

16. Division of Hematology/Oncology, School of Medicine, University of California, Irvine, CA, USA

17. Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA

18. Department of Community Dentistry and Behavioral Science, University of Florida, Gainesville, FL, USA

19. Department of Medicine in the College of Medicine, University of Florida, Gainesville, FL, USA

20. Departments of Surgery, University of Southern California, Los Angeles, CA, USA

21. Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, FL, USA

22. Department of Neurosurgery, University of Florida, Gainesville, FL, USA

23. Department of Chemistry, Florida Agricultural and Mechanical University, Tallahassee, FL USA

24. Department of Medicine, University of Southern California, Los Angeles, CA, USA

25. Department of Biochemistry and Molecular Medicine, University of Southern California, Los Angeles, CA, USA

26. Department of Radiation Oncology, University of Florida, Gainesville, FL, USA

27. College of Medicine, University of Florida, Jacksonville, FL, USA

28. Department of Clinical Physiology and Neuroscience, University of Southern California, Los Angeles, CA, USA

29. Department of Pharmaceutical Outcome and Policy, University of Florida, Gainesville, FL, USA

30. Department of Urology, College of Medicine, University of Florida, Gainesville, FL, USA

31. Department of Surgery, Virginia Commonwealth University, Richmond, VA, USA

32. Department of Surgery, University of Florida, Jacksonville, FL, USA

Abstract

Introduction The Florida-California Cancer Research, Education, and Engagement (CaRE2) Health Equity Center is a triad partnership committed to increasing institutional capacity for cancer disparity research, the diversity of the cancer workforce, and community empowerment. This article provides an overview of the structure, process innovations, and initial outcomes from the first 4 years of the CaRE2 triad partnership. Methods CaRE2 serves diverse populations in Florida and California using a “molecule to the community and back” model. We prioritize research on the complex intersection of biological, environmental, and social determinants health, working together with scientific and health disparities communities, sharing expertise across institutions, bidirectional training, and community outreach. Partnership progress and outcomes were assessed using mixed methods and four Program Steering Committee meetings. Results Research capacity was increased through development of a Living Repository of 81 cancer model systems from minority patients for novel cancer drug development. CaRE2 funded 15 scientific projects resulting in 38 publications. Workforce diversity entailed supporting 94 cancer trainees (92 URM) and 34 ESIs (32 URM) who coauthored 313 CaRE2-related publications and received 48 grants. Community empowerment was promoted via outreaching to more than 3000 individuals, training 145 community cancer advocates (including 28 Community Scientist Advocates), and publishing 10 community reports. CaRE2 members and trainees together have published 639 articles, received 61 grants, and 57 awards. Conclusion The CaRE2 partnership has achieved its initial aims. Infrastructure for translational cancer research was expanded at one partner institution, and cancer disparities research was expanded at the two cancer centers.

Funder

National Institutes of Health

National Cancer Institute

Publisher

SAGE Publications

Subject

Oncology,Hematology,General Medicine

Reference20 articles.

1. United States Census Bureau. https://www.census.gov/quickfacts/fact/table/US/PST045222#PST045222

2. American Association for Cancer Research (AACR). Cancer Disparities Progress Report. Author. https://cancerprogressreport.aacr.org/. 2022.

3. Making cancer research more inclusive

4. Role of funders in addressing the continued lack of diversity in science and medicine

5. Cancer statistics, 2023

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