Patients With Lung Cancer Have High Susceptibility of COVID-19: A Retrospective Study in Wuhan, China-Reference-Cited by-同舟云学术

Patients With Lung Cancer Have High Susceptibility of COVID-19: A Retrospective Study in Wuhan, China

Published:2020-01-01 Issue:1 Volume:27 Page:107327482096046
ISSN:1073-2748
Container-title:Cancer Control
language:en
Short-container-title:Cancer Control

Author:

Dai Meng-Yuan¹²³,Chen Zhen⁴,Leng Yan⁵,Wu Meng⁶,Liu Yu⁷,Zhou Fuxiang⁷,Ming Chen⁸,Shao Ningyi⁹,Liu Miao¹⁰^ORCID,Cai Hongbing¹²³

Affiliation:

1. Department of Gynecological Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China

2. Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China

3. Hubei Cancer Clinical Study Center, Wuhan, China

4. Department of Emergency, The Central Hospital of Wuhan affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China

5. Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, China

6. Department of Ultrasound, Zhongnan Hospital of Wuhan University, Wuhan, China

7. Department of Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China

8. Department of Genetics and Genomic Sciences, Icahn School of Medicine, Mount Sinai, NY, USA

9. Faculty of Health Sciences, University of Macau, Macau, China

10. Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

Abstract

Patients with lung cancer are presumed to be at high risk from COVID-19 infection due to underlying malignancy. A total of 31 COVID-19 patients with pre-diagnosed lung cancer and 186 age and sex matched COVID-19 patients without cancer in 6 hospitals in Wuhan, China were identified in our study. There was a significantly higher level of IL-6 in lung cancer group showed by multifactorial analysis. The restricted mean survival time in 10, 20, and 53 days in COVID-19 patients with lung cancer were ealier than non-cancer COVID-19 patients in the same observation time (all P values < 0.05). Our results indicated that pre-diagnosed lung cancer was associated with higher morbidity and mortality in COVID-19 patients.

Funder

National Natural Science Foundation of China

Publisher

SAGE Publications

Subject

Oncology,Hematology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1073274820960467

Reference20 articles.

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3. World Health Organization. Clinical management of severe acute respiratory infection when novel coronavirus (2019-nCoV) infection is suspected: interim guidance, 28 January 2020 World Health Organization; 2020.

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