Surgical and Molecular Pathology of Barrett Esophagus

Author:

Zibadi Sherma1,Coppola Domenico2

Affiliation:

1. Department of Pathology and Oncological Sciences, University of South Florida Morsani College of Medicine, Chemical Biology and Molecular Medicine, and Tumor Biology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida.

2. Departments of Anatomic Pathology, Chemical Biology and Molecular Medicine, and Tumor Biology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida.

Abstract

Background Patients with Barrett esophagus (BE) are predisposed to developing dysplasia and cancer. Adenocarcinoma, which is associated with BE, is the most common type of esophageal tumor and, typically, it has an aggressive clinical course and a high rate of mortality. Methods The English-language literature relating to tumor epidemiology, etiology, and the pathogenesis of BE was reviewed and summarized. Results The role of pathologists in the diagnosis and pitfalls associated with grading Barrett dysplasia is addressed. Current molecular testing for Barrett neoplasia, as well as testing methods currently in development, is discussed, focusing on relevant tests for diagnosing tumor types, determining prognosis, and assessing therapeutic response. Conclusions Grading is essential for developing appropriate treatment plans, follow-up visits, and therapeutic interventions for each patient. Familiarity with current molecular testing methods will help physicians correctly diagnose the disease and select the most appropriate therapy for each of their patients.

Publisher

SAGE Publications

Subject

Oncology,Hematology,General Medicine

Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Barrett’s esophagus: genetic features;Experimental and Clinical Gastroenterology;2020-06-29

2. Evaluation of p53 protein expression in Barrett esophagus;Indian Journal of Pathology and Microbiology;2018

3. Esophagitis and Barrett Esophagus;Diagnostic Pathology: Cytopathology;2018

4. DUOX2 Expression Is Increased in Barrett Esophagus and Cancerous Tissues of Stomach and Colon;Gastroenterology Research and Practice;2016

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