Multiple sclerosis and chronic cerebrospinal venous insufficiency: a critical review

Author:

Awad Amer M.1,Marder Ellen2,Milo Ron3,Stüve Olaf2

Affiliation:

1. Baton Rouge Neurology Associates, Baton Rouge General Medical Center, 3600 Florida Blvd, Baton Rouge, LA 70806, USA

2. Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Texas, USA and Neurology Section, VA North Texas Health Care System, Medical Service, Dallas, TX, USA

3. Department of Neurology, Barzilai Medical Center, Ashkelon, Israel

Abstract

Chronic cerebrospinal venous insufficiency (CCSVI) was recently proposed as a contributing factor in the pathology of multiple sclerosis. This concept has gained remarkable attention, partly because endovascular neurointervention has been suggested as a treatment strategy. This review summarizes available evidence and provides a critical analysis of the published data. Currently, there is inconclusive evidence to support CCSVI as an etiological factor in patients with multiple sclerosis. Endovascular procedures should not be undertaken outside of controlled clinical trials.

Publisher

SAGE Publications

Subject

Clinical Neurology,Neurology,Pharmacology

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