Roles of Glutamate Transporter and Receptors, Poly (ADPribose) Polymerase, and Transforming Growth Factor-β1 in Pontosubicular Neuron Necrosis-Reference-Cited by-同舟云学术

Roles of Glutamate Transporter and Receptors, Poly (ADPribose) Polymerase, and Transforming Growth Factor-β1 in Pontosubicular Neuron Necrosis

Published:2000-06 Issue:6 Volume:15 Page:362-369
ISSN:0883-0738
Container-title:Journal of Child Neurology
language:en
Short-container-title:J Child Neurol

Author:

Shu Zhen Meng ¹,Itoh Masayuki²,Obonai Toshimasa³,Takashima Sachio⁴

Affiliation:

1. Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, Department of Laboratory Medicine, National Center Hospital for Mental, Nervous, and Muscular Disorders, National Center of Neurology and Psychiatry Tokyo, Japan, Department of Pediatrics, the Second Clinical Hospital, China Medical University, eng), Shenyang, China

2. Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience

3. Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience,

4. Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, Department of Laboratory Medicine, National Center Hospital for Mental, Nervous, and Muscular Disorders, National Center of Neurology and Psychiatry Tokyo, Japan

Abstract

The expression of neuron-type glutamate transporters (EAAC-1), AMPA glutamate receptor subunits (GluR1 and GluR2/3), polyadenosine (5'diphosphate-ribose) polymerase (PARP), and transforming growth factor-β1 was investigated in 20 cases of neonatal pontosubicular neuron necrosis and 12 gestational-age matched controls. Developmental immunoreactivities of EAAC-1, GluR1, and GluR2/3 appeared in the neurons of the pontine nuclei at 29 to 30 weeks' gestation in controls, and then gradually increased with age. However, these activities were decreased in the pontine nucleus of patients with pontosubicular neuron necrosis. Decreases in these immunoreactivities might indicate early degeneration of neurons. Although PARP and transforming growth factor-β1 immunoreactivity was insignificant or very weak in the pontine nuclei at any age in controls, PARP was markedly expressed in karyorrhectic neurons of the pontine nucleus in patients with pontosubicular neuron necrosis. Transforming growth factor-β1 immunoreactivity was observed in nonkaryorrhectic neurons of the pontine nuclei. PARP could contribute to the pathogenesis of pontosubicular neuron necrosis more than EAAC-1 or GluR1 or GluR2/3. Transforming growth factor-β1 could play a role in the protection and repair of damaged neurons. ( J Child Neurol 2000;15:362-369).

Publisher

SAGE Publications

Subject

Neurology (clinical),Pediatrics, Perinatology and Child Health

Link

http://journals.sagepub.com/doi/pdf/10.1177/088307380001500602

Reference46 articles.

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