Giant Axonal Neuropathy: Diffusion-Weighted Imaging Features of the Brain

Author:

Alkan Alpay1,Sigirci Ahmet2,Kutlu Ramazan2,Doganay Selim2,Erdem Gulnur2,Yakinci Cengiz3

Affiliation:

1. Department of Radiology Inonu University School of .

2. Department of Radiology Inonu University School of Medicine

3. Department of Pediatrics Inonu University School of Medicine Malatya, Turkey

Abstract

Giant axonal neuropathy is a rare autosomal recessive childhood disorder characterized by a peripheral neuropathy and features of central nervous system involvement. Magnetic resonance imaging (MRI) of an 11-year-old boy with giant axonal neuropathy revealed high signal intensity in the white matter of the cerebrum and cerebellum on T2-weighted imaging. An apparent diffusion coefficient map revealed increased apparent diffusion coefficient values in the periventricular, deep, and cerebellar white matter, basal ganglia, and thalamus. Increased apparent diffusion coefficient values in distinct locations suggest increased mobility of water molecules in the brain of a patient with giant axonal neuropathy. This finding could indicate a myelin disorder such as demyelination. Diffusion-weighted imaging should be performed to reveal apparent diffusion coefficient changes and determine brain involvement in patients with giant axonal neuropathy. (J Child Neurol 2006;21:912—915; DOI 10.2310/7010.2006.00211).

Publisher

SAGE Publications

Subject

Neurology (clinical),Pediatrics, Perinatology and Child Health

Cited by 7 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Giant axonal neuropathy;Applied Radiology;2018-05-01

2. Unusual Neuroimaging Findings in Two Families with Giant Axonal Neuropathy;Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques;2014-11

3. Involvement of the Globus Pallidus in Giant Axonal Neuropathy;Pediatric Neurology;2012-11

4. A 6-year-old girl with progressive ataxia;Journal of Clinical Neuroscience;2012-02

5. A 6-year-old girl with progressive ataxia;Journal of Clinical Neuroscience;2012-02

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