Optic Neuritis: A Novel Presentation of Schilder's Disease

Author:

Afifi Adel K.1,Follett Kenneth A.2,Greenlee Jeremy2,Scott William E.3,Moore Steven A.4

Affiliation:

1. Departments of Pediatrics, Neurology and Anatomy and Cell Biology,

2. Department of Surgery (Neurosurgery)

3. Department of Ophthalmology

4. Department of Pathology University of Iowa Hospitals and Clinics Iowa City, Iowa

Abstract

The clinical features of a 7-year-old girl who presented with unilateral optic neuritis are presented. Magnetic resonance imaging (MRI) showed lesions in the affected optic nerve and the centrum semiovale bilaterally. Biopsy of one of the cerebral lesions was consistent with a diagnosis of Schilder's disease. Visual acuity returned to normal, and the demyelinating MRI lesions improved markedly with corticosteroid treatment. Optic neuritis is a novel mode of presentation in Schilder's disease. ( J Child Neurol 2001;16:693-696).

Publisher

SAGE Publications

Subject

Clinical Neurology,Pediatrics, Perinatology, and Child Health

Reference16 articles.

1. Zur Kenntnis der sogenannten diffusen Sklerose. (Über Encephalitis periaxialis diffusa.)

2. Poser CM: Myelinoclastic diffuse sclerosis, in Vinken P, Bruyn G (eds): Handbook of Clinical Neurology, vol 47. Amsterdam, Elsevier, 1985, 419-428.

3. Inflammatory myelinoclastic diffuse sclerosis

4. A case of myelinoclastic diffuse sclerosis in an adult

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