Israeli Children With Autism Spectrum Disorder Are not Macrocephalic

Author:

Davidovitch Michael1,Golan Dafna2,Vardi Orna2,Lev Dorit3,Lerman-Sagie Tally4

Affiliation:

1. Child Development Center, Jerusalem and Shfela District, Maccabi Healthcare Services, Israel,

2. Child Development Center, Jerusalem and Shfela District, Maccabi Healthcare Services, Israel

3. Genetic Institute, Wolfson Medical Center, Holon, Israel

4. Pediatric Neurology, Wolfson Medical Center, Holon, and Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel

Abstract

The prevalence of macrocephaly in autism spectrum disorder is reported to be much higher than in the general population, 12% to 37%. Progressive macrocephaly is even considered a warning sign for the development of autism. We evaluated the prevalence of an abnormal head circumference in children with autism in Israel and compared it with the head circumferences of children with developmental language disorder and children with normal development. We did not find a higher prevalence of macrocephaly among Israeli children with autism spectrum disorder (4.4%). Although children with autism spectrum disorder had a significantly higher rate of a head circumference above the 75th percentile compared with children with developmental language disorder, it was not significantly different compared with normal controls. We conclude that there is no increased prevalence of macrocephaly in Israeli children with autism; this can be attributed to a different genetic background.

Publisher

SAGE Publications

Subject

Neurology (clinical),Pediatrics, Perinatology and Child Health

Reference41 articles.

1. Herbert MR, Caviness VS Neuroanatomy and imaging studies. In: Hart H, ed. Autism: A Neurological Disorder of Early Brain Development . London, UK: Mac Keith Press; 2006:115-118.

2. Menkes JH, Sarnat HB, Folres-Sarnat L. Malformations of the central nervous system. In: Menkes JH, Sarnat HB, Maria BL, eds. Child Neurology. Philadelphia, PA: Lippincott Williams & Wilkins ; 2006:327-329.

3. A Case-Control Family History Study of Autism

4. Head Circumference in Autism and Other Pervasive Developmental Disorders

5. Head Circumference Measurements in Children With Autism

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