A Possible Pathophysiologic Substrate of Attention Deficit Hyperactivity Disorder

Author:

Heilman Kenneth M.1,Voeller Kytja K.S.1,Nadeau Stephen E.1

Affiliation:

1. Department of Neurology, University of Florida College of Medicine, and the Veterans Affairs Medical Center, Gainesville, FL

Abstract

The attention deficit hyperactivity disorder (ADHD) is associated with defective attention and response inhibition and motor restlessness. Inattention, defective response inhibition, and impersistence are more commonly seen in adults with right than with left hemisphere dysfunction. In light of this fact and because children with ADHD not only appear to demonstrate these symptoms but also neglect the left side and have decreased activation of their right neostriatum, we propose that these children have a right hemisphere dysfunction. In addition, because both inattention and defective response inhibition can be seen in children with ADHD and in patients and animals who have frontal lobe and striatal dysfunction, we propose that children with ADHD have dysfunction in a right-sided frontal-striatal system. Motor restlessness may reflect frontal lobe dysfunction due to impairment of the mesocortical dopamine system. (J Child Neurol 1991;6(Suppl):S74-S79).

Publisher

SAGE Publications

Subject

Clinical Neurology,Pediatrics, Perinatology, and Child Health

Reference50 articles.

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2. A simple test of visual neglect

3. Mechanisms underlying hemispatial neglect

4. Right Cerebral Dominance in Spatial Attention

5. Selective Attention in Hemispatial Neglect

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