Risperidone Use in Autism Spectrum Disorders: A Retrospective Review of a Clinic-Referred Patient Population

Author:

Lemmon Monica E.1,Gregas Matt2,Jeste Shafali S.3

Affiliation:

1. Harvard Medical School, Boston, MA, USA, The Johns Hopkins Hospital, Department of Pediatrics, Baltimore, MD, USA,

2. Harvard Medical School, Boston, MA, USA, Children's Hospital Boston, Clinical Research Department, Boston, MA, USA

3. UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA

Abstract

Risperidone is widely used in children with autism spectrum disorders for behavioral modification. In this study, the authors aimed to (1) describe a clinic-referred sample of patients with an autism spectrum disorder on risperidone, (2) identify differences between the success and nonsuccess groups, and (3) describe our experience with young children (< age 5 years) on risperidone. Eighty patients were initiated on risperidone. Indications included aggression (66%), impulsivity (14%), and stereotypies (4%). Sixty-six percent met criteria for success at 6 months and 53% at 1 year. Sixty-seven percent of the nonsuccess group reported side effects, compared to 47% of the success group. Weight gain was the most common side effect in both groups, followed by somnolence. Somnolence was the most robust predictor of nonsuccess. In our clinic-referred sample, the short-term success rate of risperidone was more than 50%, and side effects limited its use. Although weight gain was common, somnolence more significantly influenced treatment discontinuation.

Publisher

SAGE Publications

Subject

Neurology (clinical),Pediatrics, Perinatology and Child Health

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