Differential Involvement of the Brain in Neonatal Asphyxia: A Pathogenic Explanation

Author:

Sheth Raj D.1,Bodensteiner John B.2,Riggs Jack E.3,Schochet Sydney S.4

Affiliation:

1. Department of Neurology

2. Department of Pediatrics

3. Department of Medicine

4. Department of Pathology, West Virginia University Health Sciences Center, Morgantown, WV

Abstract

Multiple cystic lesions in brain parenchyma supplied by the anterior cerebral circulation is a recognized pattern of cerebral injury associated with hypoxic-ischemic encephalopathy in the term infant. This report presents a series of seven infants (gestational age, 39.3 ± 2.8 weeks; range, 36 to 44 weeks) who developed multicystic encephalomalacia in the distribution of the anterior cerebral circulation after severe neonatal asphyxia. Cerebral imaging and pathologic studies demonstrate relative preservation of the cerebellum, brain stem, and cerebral structures supplied by the vertebrobasilar circulation. Compared to the vertebrobasilar vasculature, the anterior cerebral vessels in the term infant have dense sympathetic innervation. Asphyxia, a potent sympathetic stimulator, may induce vasoconstriction in the anterior circulation and differentially accentuate the effects of hypoxia/ischemia on cerebral tissue. (J Child Neurol 1995;10:464-466).

Publisher

SAGE Publications

Subject

Neurology (clinical),Pediatrics, Perinatology and Child Health

Reference26 articles.

1. Cluster of perinatal events identifying infants at high risk for death or disability

2. Volpe JJ: Hypoxic-ischemic encephalopathy: Neuropathology and pathogenesis, in Volpe JJ (ed): Neurology of the Newborn. Philadelphia, WB Saunders, 1987, pp 209-232.

3. Periventricular Leukomalacia of Infancy

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