Affiliation:
1. Department of Hematology/Oncology/Stem Cell Transplantation, Children's Memorial Hospital, Chicago, Illinois,
Abstract
Pediatric high-grade gliomas represent approximately 10% of all pediatric brain tumors. Similar to adult high-grade gliomas, they behave very aggressively, and these children have a very poor prognosis despite a variety of therapies that include chemotherapy and radiotherapy. In this review, we present an overview of both pediatric high-grade gliomas and diffuse intrinsic pontine gliomas with a focus on their epidemiology, etiology, presentation, prognostic factors, biology, treatment modalities, outcomes, and future research directions.
Subject
Neurology (clinical),Pediatrics, Perinatology and Child Health
Cited by
79 articles.
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