Embryonal Tumor With Abundant Neuropil and True Rosettes

Author:

Alexiou George A.1,Stefanaki Kalliopi2,Vartholomatos George3,Sfakianos George1,Prodromou Neofytos1,Moschovi Maria4

Affiliation:

1. Department of Neurosurgery, Children’s Hospital “Agia Sofia,” Athens, Greece

2. Department of Pathology, Children’s Hospital “Agia Sofia,” Athens, Greece

3. Haematology Laboratory, Unit of Molecular Biology, University Hospital of Ioannina, Ioannina, Greece

4. Hematology Oncology Unit of 1st Department of Pediatrics of Athens University, Athens, Greece

Abstract

Embryonal tumor with abundant neuropil and true rosettes has been recently defined as a distinct central nervous system embryonal neoplasm, although it was initially regarded as a subtype of central nervous system primitive neuroectodermal tumor. To date 70 cases have been reported. We have performed a literature review and we present 2 new cases. Analysis of the reported data revealed that radiotherapy, tumor excision and high-dose adjuvant chemotherapy with sequential autologous hematopoietic stem cell rescue have a prognostic significance.

Publisher

SAGE Publications

Subject

Neurology (clinical),Pediatrics, Perinatology and Child Health

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