Plasma Baclofen Levels in Children Receiving Continuous Intrathecal Baclofen Infusion

Author:

Albright A. Leland1,Shultz Barbara L.1

Affiliation:

1. Department of Neurosurgery Children's Hospital of Pittsburgh Pittsburgh, Pennsylvania

Abstract

To determine the plasma baclofen concentrations of children undergoing continuous intrathecal baclofen infusion for treatment of cerebral spasticity, we assayed plasma samples from six children, 8 to 18 years of age, who were receiving intrathecal baclofen at constant rates of 77 to 400 μg/day. Plasma levels were at or below the limit of quantification (10 ng/mL) in all patients. (J Child Neurol 1999;14:408-409).

Publisher

SAGE Publications

Subject

Clinical Neurology,Pediatrics, Perinatology, and Child Health

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