Radiopharmaceuticals for the palliation of painful bone metastases

Author:

Reisfield Gary M.1,Silberstein Edward B.2,Wilson George R.3

Affiliation:

1. Division of Palliative Medicine, Department of Community Health and Family Medicine, University of Florida Health Science Center, Jacksonville, Florida

2. University of Cincinnati Medical Center, Cincinnati, Ohio

3. Department of Community Health and Family Medicine, University of Florida Health Science Center, Jacksonville, Florida

Abstract

Metastatic bone pain is prevalent in advanced cancer, and, despite a plethora of available therapies, effective palliation remains a clinical challenge. Bone-seeking radiopharmaceuticals are an often-overlooked but valuable analgesic option for select patients. These agents work by binding to hydroxyapatite at the tumor-bone interface of osteoblastic lesions, delivering therapeutic doses of radiation to closely circumscribed tissue regions. They have been shown to reduce pain and improve quality of life. Their safety, simplicity, convenience of administration, and cost-effectiveness make them suitable for hospice and palliative care settings.

Publisher

SAGE Publications

Subject

General Medicine

Cited by 11 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Bone-Targeting Radiopharmaceuticals as Monotherapy or Combined With Chemotherapy in Patients With Castration-Resistant Prostate Cancer Metastatic to Bone;Clinical Genitourinary Cancer;2019-04

2. Hybrid Imaging and Radionuclide Therapy of Musculoskeletal Diseases;Nuclear Medicine Textbook;2019

3. Radiotherapy of Skeletal Metastases;Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism;2018-09-28

4. Modern Palliative Treatments for Metastatic Bone Disease;The Clinical Journal of Pain;2016-04

5. Metastatic Bone Tumor Therapy;Diagnostic Imaging: Nuclear Medicine;2016

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