Methadone

Author:

Chhabra Shalini1,Bull Janet2

Affiliation:

1. Department of Medicine, East Tennessee State University, and Home-Based Primary Care, James H. Quillen Veterans Affairs Medical Center at Mountain Home, Johnson City, Tenessse,

2. Four Season's Hospice and Palliative Care, Hendersonville, North Carolina

Abstract

Methadone hydrochloride is an old drug that has been in vogue off and on. It has complex pharmacodynamics and can be potentially fatal in inexperienced settings. Drug switching from an opioid to methadone or vice versa requires knowledge of equianalgesic dosing. It is critical when using the drug to monitor for signs and symptoms of toxicity so that overdosing or toxicity can be identified in a timely manner. This review discusses these important topics so that methadone can be used safely and effectively.

Publisher

SAGE Publications

Subject

General Medicine

Reference44 articles.

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4. THE EFFECT OF CHANGES IN GASTRIC pH INDUCED BY OMEPRAZOLE ON THE ABSORPTION AND RESPIRATORY DEPRESSION OF METHADONE

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