Natural History and Clinical Significance of Multiple Cysts in a Single Choroid Plexus

Abstract

Different types and locations of choroid plexus cysts (CPCs) have been described, including oversized and bilateral. It appears that the type, size, and number of CPCs are correlated with various degrees of aneuploidy risk. This report deals with the natural history and significance of CPCs filling only one choroid plexus. Multiple CPCs filling the entire choroid plexus were detected in 9 of 4211 consecutive second-trimester sonographic examinations. Karyotyping via amniocentesis or neonatal blood analysis was performed in all cases. CPCs in a single choroid plexus were associated with transient ventriculomegaly in five of nine fetuses. Resolution of CPCs took place between 25 and 33 weeks of pregnancy, with most resolving after the 30th week. Karyotyping revealed normal results in all cases. Favorable prognosis of newly described multiple CPCs in a single choroid plexus should be mentioned during patient counseling.