A finite element investigation on plaque vulnerability in realistic healthy and atherosclerotic human coronary arteries

Abstract

Atherosclerosis is the most common arterial disease. It has been shown that stresses that are induced during blood circulation can cause plaque rupture and, in turn, lead to thrombosis and stroke. In this study, finite element method is used to predict plaque vulnerability based on peak plaque stress using human samples. A total of 23 healthy and atherosclerotic human coronary arteries of 14 healthy and 9 atherosclerotic patients are excised within 5 h postmortem. The samples are mounted on an uniaxial tensile test machine, and the obtained mechanical properties are used in two-dimensional and three-dimensional finite element models. The results including the Neo–Hookean hyperelastic coefficients of the samples as well as peak plaque stresses are analyzed. The results indicate that the atherosclerotic human coronary arteries have significantly ( p < 0.05) higher stiffness compared with the healthy ones. The hypocellular plaque also has the highest stress values and, as a result, is most likely (vulnerable) to rupture, while the calcified type has the lowest stress values and, consequently, is expected to remain stable. The results could be used in the plaque vulnerability anticipation and have clinical implications in interventions and surgeries, including balloon angioplasty, bypass, and stenting.