Characterization and evaluation of multiple biological activities of phytosynthesized gold nanoparticles using aqueous extract of <i>Euphorbia dendroides</i>-Reference-Cited by-同舟云学术

Characterization and evaluation of multiple biological activities of phytosynthesized gold nanoparticles using aqueous extract of Euphorbia dendroides

Published:2022-01 Issue: Volume:12 Page:184798042211412
ISSN:1847-9804
Container-title:Nanomaterials and Nanotechnology
language:en
Short-container-title:Nanomaterials and Nanotechnology

Author:

Abd El-Moaty Heba Ibrahim¹²^ORCID,Ismail Eman H.³,Abu-Khudir Rasha⁴⁵,Soliman Nadia A.²,Sabry Dina Y.³,Al Abdulsalam Najla K.¹,Sorour Wafaa A.⁶⁷,Khalil Mostafa M.H.³

Affiliation:

1. Department of Biological Sciences, College of Science, King Faisal University, Al-Ahsa, Saudi Arabia

2. Medicinal and Aromatic Plants Department, Desert Research Center El-Mataria, Cairo, Egypt

3. Chemistry Department, Ain Shams University, Faculty of Science, Abbassia, Cairo, Egypt

4. Chemistry Department, College of Science, King Faisal University, Al-Hofuf, Al-Ahsa, Saudi Arabia

5. Chemistry Department, Biochemistry Branch, Faculty of Science, Tanta University, Tanta, Egypt

6. Department of Basic Sciences, Preparatory Year Deanship, King Faisal University, Al-Ahsa, Saudi Arabia

7. Department of Botany, Faculty of Science, Aswan University, Aswan, Egypt

Abstract

Novel metallic nanoparticles (NPs), such as biosynthesized gold nanoparticles (AuNPs), have been extensively studied because of their wide applications. Consequently, the present investigation aimed at the biosynthesis, characterization, and comparative assessment of biological activities of AuNPs. Biosynthesized AuNPs (ED-AuNPs) were synthesized using aqueous extract of Euphorbia dendroides ( E. dendroides) aerial parts (EDAE), which functions as a reducing and stabilizing agent by its nature. Presence of tannins, saponins, flavonoids, alkaloids, glycosides/or carbohydrates, steroids, and terpenes was revealed by the qualitative phytochemical analysis of EDAE. Characterization of the biosynthesized AuNPs was attained by UV-Visible spectrophotometry, transmission electron microscopy (TEM), XRD, and Fourier transform infrared (FTIR). The cytotoxic effects of ED-AuNPs and EDAE were assessed in vitro against HepG2 and HCT-116 cancer cells. The MTT assay revealed a significant cytotoxic effect of ED-AuNPs and EDAE on HepG2 (IC50 = 41.72 ± 1.26 and 55.26 ± 2.25 μg mL−1) as well as HCT-116 (IC50 = 44.96 ± 3.23 and 69.83 ± 0.96 μg mL−1) cells, thus indicating their potential anticancer activity. Furthermore, ED-AuNPs exhibited potent anti-diabetic activity, with an IC50 value of 19.8 ± 1.97 µg mL−1, pointing to their plausible use as therapeutics in the treatment of diabetes, as well as a promising antimicrobial activity against H. pylori.

Funder

Deanship of Scientific Research, Vice Presidency for Graduate Studies and Scientific Research, King Faisal University, Saudi Arabia

Publisher

SAGE Publications

Subject

Electrical and Electronic Engineering,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Biotechnology

Link

http://journals.sagepub.com/doi/pdf/10.1177/18479804221141266

Reference125 articles.

1. Review on Methodologies Used in the Synthesis of Metal Nanoparticles: Significance of Phytosynthesis Using Plant Extract as an Emerging Tool

2. Plant-based gold nanoparticles; a comprehensive review of the decade-long research on synthesis, mechanistic aspects and diverse applications

3. Current developments in green synthesis of metallic nanoparticles using plant extracts: a review

4. Green Synthesis of Metallic Nanoparticles Using Some Selected Medicinal Plants from Southern Africa and Their Biological Applications

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Nature’s Green Potential: Anticancer Properties of Plants of the Euphorbiaceae Family;Cancers;2023-12-25