Radiation-Induced Fibrosis in Patients with Head and Neck Cancer: A Review of Pathogenesis and Clinical Outcomes

Author:

Ramia Paul1,Bodgi Larry2,Mahmoud Dima2,Mohammad Mohammad A2,Youssef Bassem2,Kopek Neil1,Al-Shamsi Humaid345,Dagher Mona2,Abu-Gheida Ibrahim346

Affiliation:

1. McGill University Health Centre, Montreal, QC, Canada

2. Department of Radiation Oncology, American University of Beirut Medical Center, Beirut, Lebanon

3. Burjeel Cancer Institute, Abu-Dhabi, United Arab Emirates

4. Emirates Oncology Society, Dubai, United Arab Emirates

5. University of Sharjah, Sharjah, United Arab Emirates

6. United Arab Emirates University, Al Ain, United Arab Emirates

Abstract

Radiotherapy-related fibrosis remains one of the most challenging treatment related side effects encountered by patients with head and neck cancer. Several established and ongoing novel therapies have been studied with paucity of data in how to best treat these patients. This review aims to provide researchers and health care providers with a comprehensive review on the presentation, etiology, and therapeutic options for this serious condition.

Publisher

SAGE Publications

Subject

Oncology

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