Circadian Clock Dysregulation and Prostate Cancer: A Molecular and Clinical Overview

Author:

Kaakour Dalia1ORCID,Fortin Bridget2,Masri Selma2,Rezazadeh Arash1

Affiliation:

1. Division of Hematology/Oncology, Department of Medicine, University of California, Irvine, Orange, CA, USA

2. Department of Biological Chemistry, University of California, Irvine, Irvine, CA, USA

Abstract

Circadian clock dysregulation has been implicated in various types of cancer and represents an area of growing research. However, the role of the circadian clock in prostate cancer has been relatively unexplored. This literature review will highlight the potential role of circadian clock dysregulation in prostate cancer by examining molecular, epidemiologic, and clinical data. The influence of melatonin, light, night shift work, chronotherapy, and androgen independence are discussed as they relate to the existing literature on their role in prostate cancer.

Publisher

SAGE Publications

Subject

Oncology

Reference112 articles.

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2. Key statistics for prostate cancer. https://www.cancer.org/cancer/types/prostate-cancer/about/key-statistics.html.

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