Affiliation:
1. dalla III Divisione di Medicina Generale dell'Ospedale Civile di Brescia, diretla dal prof. F. Balestrieri
Abstract
Prostatic carcinoma causes early microemboli of tumour cells to the bone marrow, and frequent bone metastases. A myelogram was carried out in 30 subjects with established prostatic neoplasm, 6 of whom with radiologically evident bone metastases. Metastatic tumour cells were found in 2 cases only. In 16 cases the myelogram modification was unrelevant, in the remaining 12 cases some particular changes were demonstrated. These changes, although non-specific, seem to be the result of a conspicuous micro-embolism of tumour cells in the bone marrow; they consist in isolate or associate pictures of hyper-erythroblastosis, disproportionate to the degree of peripheral anemia, of plasmacell reaction, of reticular and lymphoidoreticular hyperplasia; the latter is related to particular changes of protein metabolism.
Subject
Cancer Research,Oncology,General Medicine