Intestinal-Type Adenocarcinoma of the Sinonasal Tract: A Clinicopathologic Study of 18 Cases

Author:

Urso Carmelo1,Ninu Maria Benedetta2,Franchi Alessandro1,Paglierani Milena1,Bondi Roberto1

Affiliation:

1. Istituto di Anatomia e Istologia Patologica, Università di Firenze

2. Clinica Otorinolaringoiatrica II, Università di Firenze

Abstract

Background Intestinal-type adenocarcinoma (ITAC) of the nose and paranasal sinuses is a relatively rare tumor. It commonly affects subjects exposed to wood or leather dust. Methods The authors present the clinicopathologic findings of 18 cases of sinonasal ITACs and review the proposed histologic classifications. Results All patients, except one, were males; mean age was 60 years (range, 41-79); in 9 cases an occupational exposure to wood or leather dust was found. Common presenting symptoms were epistaxis, nasal obstruction and rhinorrhea. Histologically, tumors were divided into four groups: well-differentiated (G1) ITACs = 3 cases; moderately differentiated (G2) ITACs = 8 cases; poorly differentiated (G3) ITACs = 2 cases; mucinous (M) ITACs = 5 cases. Immunocytochemically, 16/17 cases were positive for carcinoembryonal antigen, 1/17 for somatostatin, and 0/16 cases for gastrin. Conclusions Sinonasal ITACs are aggressive tumors, often diagnosed in a relatively advanced stage. Owing the close similarity of the microscopic aspects, a histologic classification of ITACs analogous to that of colonic adenocarcinomas is proposed.

Publisher

SAGE Publications

Subject

Cancer Research,Oncology,General Medicine

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1. Neoplasms of the Sinonasal Tract;Atlas of Head and Neck Pathology;2023

2. Nonsquamous Lesions of the Nasal Cavity, Paranasal Sinuses, and Nasopharynx;Gnepp's Diagnostic Surgical Pathology of the Head and Neck;2021

3. Malignant Neoplasms of the Nasal Cavity, Paranasal Sinuses, and Nasopharynx;Head and Neck Pathology;2019

4. Sinonasal Adenocarcinoma, Intestinal Type;Diagnostic Pathology: Head and Neck;2016

5. Neoplasms of the Sinonasal Tract;Atlas of Head and Neck Pathology;2016

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