Affiliation:
1. (Servizio di Anatomia ed Istologia Patologica, Ospedale S. Salvatore, USL n. 3, Pesaro)
Abstract
A case of Paget's disease and gynecomastia in a 70-year-old man is reported. Paget's disease was connected to an intraductal carcinoma, and the immunohistochemical study revealed similar positivity for cytokeratin A, carcinoembryonic antigen and epithelial membrane antigen in Paget cells and intraductal neoplastic cells whereas Paget cells resulted negative for cytokeratin B and C. The study using monoclonal anti-cytokeratin A (35 βH11), B (34 βE12) and C (34 βB4) could represent a good tool, supporting the theory of a ductal origin of Paget cells. A review of the literature has shown the rarity of Paget's disease in the male breast and revealed only two previous reports with an associated gynecomastia, in 2 patients with Klinefelter's syndrome and infiltrating breast carcinoma.
Subject
Cancer Research,Oncology,General Medicine
Cited by
6 articles.
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1. Enfermedad de Paget;EMC - Dermatología;2012-09
2. Maladie de Paget;EMC - Dermatologie;2012-05
3. Maladie de Paget;Manifestations dermatologiques des maladies du système hématopoïétique et oncologie dermatologique;2009
4. Mammary and extramammary Paget's disease;Journal of the European Academy of Dermatology and Venereology;2007-03-28
5. BREAST CANCER IN MEN;Surgical Clinics of North America;1996-04