Affiliation:
1. Centro Studio Tumori, Ospedale di Circolo, Busto Arsizio
Abstract
Intraperitoneally or subcutaneously injected narciclasine exerts an inhibiting activity on the mitoses of ascites Sarcoma 180. According to the dosage mitoses are blocked at metaphase or at preprophase. For the highest doses a mitoclasic effect is also present. Mitoses of duodenal mucosa and of bone marrow were much less affected by narciclasine.
Subject
Cancer Research,Oncology,General Medicine
Cited by
8 articles.
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1. Haemanthus coccineus
extract and its main bioactive component narciclasine display profound anti‐inflammatory activities
in vitro
and
in vivo;Journal of Cellular and Molecular Medicine;2015-03-05
2. (2S,3R,4S,4aR)-2,3,4,7-Tetrahydroxy-3,4,4a,5-tetrahydro[1,3]dioxolo[4,5-j]phenanthridin-6(2H)-one hemihydrate;Acta Crystallographica Section E Structure Reports Online;2012-12-05
3. Narciclasine as well as other Amaryllidaceae Isocarbostyrils are Promising GTP-ase Targeting Agents against Brain Cancers;Medicinal Research Reviews;2012-03-14
4. Bioactive substances from the Chinese daffodil,Narcissus tazetta;Phytotherapy Research;1992-09
5. Slow release of narciclasine from matrices obtained by radiation-induced polymerization;Journal of Controlled Release;1991-08