Exacerbation of Metastatic Disease Shortly after Administration of Tamoxifen in ER Negative Advanced Breast Carcinoma. A Case Report

Author:

Cocconi Giorgio1,Boni Corrado1,Naldi Nadia1,Nizzoli Rita1,Bozzetti Cecilia1

Affiliation:

1. (Medical Oncology Service, Ospedale Maggiore, Parma)

Abstract

In a patient with long untreated slow-growing osteoblastic bone metastases from an ER/PgR negative breast carcinoma, new metastatic sites in many lymphnodes pleura and massively in liver have been observed 4 weeks after receiving tamoxifen. Cause-effect relationship between administration of the drug and this unusually rapid spreading of the disease may be considered only as a hypothesis, as it is based wholly on clinical outcome. However, reporting of any exacerbation of breast cancer apparently induced by tamoxifen, even if only anecdotal, is advisable.

Publisher

SAGE Publications

Subject

Cancer Research,Oncology,General Medicine

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