Epirubicin in Combination Chemotherapy in the Treatment of Advanced Stage Non-Hodgkin's Lymphomas

Author:

Abate Giuseppe1,Cornelia Pasquale1,Di Pietro Nicola2,Ganzina Fabrizio2,Pergola Mario1,Silvestro Pasqualina1,Basso Antonio1,Salvatore Marco1,Zarrilli Donate1

Affiliation:

1. Istituto per lo Studio e la Cura dei Tumori, Naples

2. R. & D. Farmitalia Carlo Erba, Milan, Italia

Abstract

From April 1981 to May 1984, 23 patients with advanced non-Hodgkin's lymphomas were treated with CEOP (cyclophosphamide, epirubicin, vincristine, and prednisone) or OEPP (vincristine, epirubicin, procarbazine, and prednisone) combination chemotherapy. CR was achieved in 58 % and PR in 31 % of the patients, giving an overall response rate of 89 %. Nine of 15 (60 %) previously untreated patients with unfavorable histology obtained a CR and 5 a PR. Median relapse-free survival was 33 months; median overall survival has not yet been reached, and the probability of survival for CRs was 91 % after 54 months of follow-up. Acute toxicity was quite acceptable, and chronic cardiac toxicity was detected in 6 patients only. In conclusion, epirubicin used in combination chemotherapies induced durable remissions and prolonged survivals in advanced non-Hodgkin's lymphomas.

Publisher

SAGE Publications

Subject

Cancer Research,Oncology,General Medicine

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