Clinical Management of a Case of Recurrent Apocrine Gland Carcinoma of the Scalp: Efficacy of a Chemotherapy Schedule with Methotrexate and Bleomycin

Author:

Morabito Alessandro1,Bevilacqua Pierantonio2,Vitale Stefano1,Fanelli Massimo1,Gattuso Domenico1,Gasparini Giampietro1

Affiliation:

1. Division of Medical Oncology, Azienda Ospedaliera “Bianchi-Melacrino Morelli”, Reggio Calabria

2. Institute of Pathology, General Hospital of Vicenza, Italy

Abstract

Apocrine carcinoma of the skin is a rare tumor. Wide surgical excision with complete removal of the neoplasm is the standard therapy and this appears to offer the best chance of cure. Radiotherapy may be used in case of local relapse or regional lymph node involvement. Systemic chemotherapy has not proved to be effective in the treatment of this tumor. We report on a 46-year-old woman with a recurrent apocrine carcinoma of the scalp that had previously been treated with surgery, radiotherapy and chemotherapy (Al-Saraff schedule). The patient was responsive to a second-line systemic chemotherapy regimen consisting of a weekly combination of methotrexate and bleomycin, and achieved long-term progression-free survival.

Publisher

SAGE Publications

Subject

Cancer Research,Oncology,General Medicine

Reference17 articles.

1. AbenozaP., AckermanA.B.: Neoplasms with eccrine differentiation, pp. 253–272, Lea and Febiger, Philadelphia, 1990.

2. Tubular apocrine adenoma with perineural invasion

3. Apocrine Gland Carcinoma of the Axilla

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