Alteration of Opioid Peptide Circadian Rhythm in Cancer Patients

Author:

Barni Sandro1,Lissoni Paolo1,Rovelli Franco1,Crispino Sergio1,Paolorossi Franco1,Esposti Daniele2,Esposti Germana2,Fraschini Franco2,Tancini Gabriele1

Affiliation:

1. Division of Radiation Oncology, Ospedale San Gerardo, Monza

2. Department of Chemotherapy, University of Milan

Abstract

Endogenous opioid peptides have been seen to play a role in regulating immunity and tumor growth. This study was carried out to investigate opioid activity in human cancer. We evaluated by radioimmunoassay β-endorphin plasma levels on blood samples collected at 9.00 a.m. from 121 cancer patients and 42 healthy subjects. In 22 cancer patients and in 12 controls, β-endorphin circadian rhythm was also investigated. Finally, in 14 cancer patients and in 10 controls GH, PRL, FSH, LH and Cortisol serum levels were measured after the administration of a metenkephalin analogue, FK 33–824 (0.3 mg i.v.). No significant differences were seen in β-endorphin mean levels between cancer patients and normal subjects. Moreover, no differences were found between patients with or without metastases, nor between those with or without chronic pain. β-Endorphin circadian rhythm appeared to be altered in 16/22 cancer patients, and anomalous hormonal responses to FK 33–824 were seen in 13/14 patients. This study shows an altered opioid activity in human neoplasms, whose clinical significance remains to be determined.

Publisher

SAGE Publications

Subject

Cancer Research,Oncology,General Medicine

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