Affiliation:
1. Institute of Pathological Anatomy and Histology, 1st Chair, Division of Cancer Research
2. Department of Hygiene, Perugia University
Abstract
5-Fluorouracil, a drug mainly used in the treatment of gastrointestinal tract neoplasms, was administered i.p. to BALB/c mice at the dose of 30 mg/kg body weight once a week for 50 weeks to test its carcinogenicity. The treatment induced a significant increase in lung tumor in both sexes (males, p < 0.05; females, p < 0.01) and tumors of the lymphoreticular system in female mice (p < 0.001). These results suggest that 5-fluorouracil is carcinogenic in mice.
Subject
Cancer Research,Oncology,General Medicine
Cited by
8 articles.
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