Protective Effect of Reduced Glutathione against CIS-Dichlorodiammine Platinum (II)–Induced Nephrotoxicity and Lethal Toxicity-Reference-Cited by-同舟云学术

Protective Effect of Reduced Glutathione against CIS-Dichlorodiammine Platinum (II)–Induced Nephrotoxicity and Lethal Toxicity

Published:1983-04 Issue:2 Volume:69 Page:105-111
ISSN:0300-8916
Container-title:Tumori Journal
language:en
Short-container-title:Tumori

Author:

Zunino Franco¹,Tofanetti Odoardo²,Besati Adriana²,Cavalletti Ennio²,Savi Giuseppina¹

Affiliation:

1. Istituto Nazionale per lo Studio e la Cura del Tumori, Milan

2. Divisione Farmacologica, Boehringer Biochemia Robin, Milan

Abstract

Pretreatment of Swiss mice and Sprague-Dawley rats with glutathione (GSH) reduced the acute lethal toxicity of cis-dichlorodiammine platinum (II) (cis-DDP) in a dose-dependent manner. The protection was accompanied by reduction of both body weight loss and by reduction of nephrotoxicity, as measured by a rise in serum blood urea nitrogen (BUN), creatinine levels and by histopathologic changes, which occurred 4 days following cis-DDP treatment. The antitumor effects of cis-DDP on experimental tumor models (P388 and Gross leukemia) were not significantly altered by GSH treatment. It is suggested that the partial protection by GSH from acute toxicity of the antitumor drug is directly related to protection of renal function.

Publisher

SAGE Publications

Subject

Cancer Research,Oncology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/030089168306900204

Reference25 articles.

1. Effects of certain antitumor platinum compounds on kidney esterases

2. Interactions of platinum complexes with the essential and nonessential sulfhydryl groups of thymidylate synthetase

3. The effects of platinum complexes on seven enzymes

4. Estimation and identification of thiols in rat spleen after cysteine or glutathione treatment: Relevance to protection against nitrogen mustards

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