Chemotherapy in Metastatic Nonanaplastic Thyroid Cancer: Experience at the Institut Gustave-Roussy

Author:

Droz Jean-Pierre1,Schlumberger Martin2,Rougier Philippe1,Ghosn Marwane1,Gardet Paule2,Parmentier Claude2

Affiliation:

1. From the Department of Medicine, Institut Gustave-Roussy, Villejuif, France

2. Department of Radiation, Institut Gustave-Roussy, Villejuif, France

Abstract

Forty-nine patients with metastatic nonanaplastic thyroid carcinoma were treated over a 10-year period. Five successive chemotherapeutic protocols were used: a combination of doxorubicin, etoposide, 5-fluorouracil and cyclophosphamide; elliptinium acetate; doxorubicin; cispiatin; and the combination of doxorubicin and cispiatin. Results obtained with the different protocols were very disappointing, with only two objective responses (3%). Phase II trials with new chemotherapeutic agents are warranted in selected cases of nonanaplastic metastatic thyroid carcinoma.

Publisher

SAGE Publications

Subject

Cancer Research,Oncology,General Medicine

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