Alteration in Natural Resistance of Sarcoma 180 Tumor to Bouvardin (NSC 259968) following Hyperthermia-Reference-Cited by-同舟云学术

Alteration in Natural Resistance of Sarcoma 180 Tumor to Bouvardin (NSC 259968) following Hyperthermia

Published:1983-08 Issue:4 Volume:69 Page:309-312
ISSN:0300-8916
Container-title:Tumori Journal
language:en
Short-container-title:Tumori

Author:

Adwankar Manohar K.¹,Chitnis Manik P.¹

Affiliation:

1. (Cellular Chemotherapy Unit, Cancer Research Institute, Tata Memorial Centre, Parel, Bombay, India)

Abstract

Sarcoma-180 (S-180) tumor cells grown in Swiss mice displayed natural resistance to Bouvardin (NSC 259968) when administered alone in a single dose or in multiple doses. Hyperthermia treatment (43 °C for 1 hr) alone did not show any tumor growth reduction. However, the drug combined with hyperthermia markedly reduced tumor growth suggesting that hyperthermia alters the natural resistance of S-180 cells to Bouvardin.

Publisher

SAGE Publications

Subject

Cancer Research,Oncology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/030089168306900406

Reference19 articles.

1. Effect of Bouvardin (NSC 259968) on the Growth Characteristics and Nucleic Acids and Protein Syntheses Profiles of P388 Leukemia Cells

2. Biochemical Parameters of Resistance of an Adriamycin-Resistant Subline of P388 Leukemia to Emetine, an Inhibitor of Protein Synthesis

3. Induced Resistance in Leukaemia L1210 to Adriamycin and Its Cross-Resistance to Vincristine and Bouvardin

4. The Effects of Hyperthermia in Animal Tumour Systems

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