Randomized Trial of Chemoimmunotherapy in Advanced Non-Oat-Cell Lung Cancer-Reference-Cited by-同舟云学术

Randomized Trial of Chemoimmunotherapy in Advanced Non-Oat-Cell Lung Cancer

Published:1982-12 Issue:6 Volume:68 Page:527-530
ISSN:0300-8916
Container-title:Tumori Journal
language:en
Short-container-title:Tumori

Author:

Rosso Riccardo¹,Nobile Maria Teresa¹,Brema Fulvio¹,Porcile Gianfranco¹,Cinquegrana Angela²,De Palma Mario³,Rubagotti Alessandra¹

Affiliation:

1. Istituto Scientifico per lo Studio e la Cura dei Tumori, Genova

2. Ospedali Civili di Genova, V Divisione di Pneumologia, Genova

3. Ospedali Civili di Genova, Divisione di Broncologia, Genova

Abstract

Thirty patients without any prior chemotherapy and histologically proved non-oat-cell advanced lung cancer entered a randomized trial comparing a combination chemotherapeutic regimen (cyclophosphamide, methotrexate, BCNU) and the same combination plus intradermic BCG. Twenty-nine patients were evaluable for survival. Mean survival was 11 and 3.5 months for chemotherapy and chemoimmunotherapy group, respectively. The difference was statistically significant (P < 0.025). A tumor enhancement can be postulated. Skin tests before treatment (PPD, Candida, Varidase) seem to be prognostic for survival.

Publisher

SAGE Publications

Subject

Cancer Research,Oncology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/030089168206800613

Reference23 articles.

1. Factor time for active immunotherapy after cytoreductive chemotherapy

2. Immunotherapy of a Solid Tumor (Melanoma) with BCG: A Comment on the Risks of Enhancement

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