A Study on the Etiological Factors of Bilharzial Bladder Cancer in Egypt. 6. The Possible Role of Urinary Bacteria-Reference-Cited by-同舟云学术

A Study on the Etiological Factors of Bilharzial Bladder Cancer in Egypt. 6. The Possible Role of Urinary Bacteria

Published:1982-02 Issue:1 Volume:68 Page:23-28
ISSN:0300-8916
Container-title:Tumori Journal
language:en
Short-container-title:Tumori

Author:

El-Aaser Abdelbaset Anwer¹,El-Merzabani Mahmoud Mohamed¹,Higgy Nadia Ahmed¹,El-Habet Abdel E.²

Affiliation:

1. Department of Cancer Biology, National Cancer Institute Cairo University, Egypt

2. Medical Research Institute, Alexandria University, Egypt

Abstract

A correlation was obtained between a positive nitrite test in urine and the severity of urinary bacterial infection. Bacteria isolated from the urine of bilharzial or bladder cancer patients were found to be rich in nitrate reductase activity. « Escherichia coli » was the most common microorganism isolated from these specimens. Urine and several urinary constituents activate bacterial nitrate reductase. β-Glucuronidase activity in the urine of patients with chronic « Schistosoma haematobium » infection and bladder cancer was measured and shown to be significantly greater than that of urine of normal control subjects. Urinary bacterial infection was shown to be the source of the increased urinary level of enzyme activity at pH 7.0.

Publisher

SAGE Publications

Subject

Cancer Research,Oncology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/030089168206800105

Reference26 articles.

1. Urinary beta-glucuronidase enzyme activity in some Bilharzial urinary tract diseases

2. Possible Microbial Contribution to Nitrosamine Formation in Sewage and Soil

3. Hydrolysis of Conjugated Steroids by Bacterial Glucuronidase

4. The Activity of the Enzymes Sulphatase and β-Glucuronidase in the Urine, Serum and Bladder Tissue

5. From the Royal School of Medicine, Cairo. THE INCIDENCE OF CANCER IN EGYPT.

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1. Nitrosating activity inEscherichia coli;FEMS Microbiology Letters;1992-08

2. Involvement of alkylating agents in schistosome-associated bladder cancer: the possible basic mechanisms of induction;Cancer Letters;1992-04-30

3. Clastogenic activity in urine of individuals with urinary bladder infections;Cancer Letters;1989-09

4. Nitrosamine formation by clinical isolates of enteric bacteria;FEMS Microbiology Letters;1988-06

5. Screening of microorganisms for nitrosation catalysis at pH 7 and kinetic studies on nitrosamine formation from secondary amines by E. coli strains;Carcinogenesis;1985