Emerging functions of PRKDC in the initiation and progression of cancer-Reference-Cited by-同舟云学术

Emerging functions of PRKDC in the initiation and progression of cancer

Published:2020-08-31 Issue:6 Volume:107 Page:483-488
ISSN:0300-8916
Container-title:Tumori Journal
language:en
Short-container-title:Tumori

Author:

Yin Yuting¹,He Qinglian¹,Li Yuling²,Long Jiali¹,Lei Xue¹,Li Ziqi¹,Zhu Wei¹^ORCID

Affiliation:

1. Department of Pathology, Guangdong Medical University, Dongguan, Guangdong Province, China

2. Department of Pathology, Dongguan Hospital of Southern Medical University, Dongguan, Guangdong Province, China

Abstract

The DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is encoded by the protein kinase, DNA-activated, catalytic polypeptide ( PRKDC) gene. DNA-PKcs plays a major role in nonhomologous end joining DNA repair, and it has been identified to be an important factor in tumor progression and metastasis. DNA-PKcs may have opposite effects in diseases, depending on the cell and tissue types. In this review, we discuss its role in various tumors. High levels of DNA-PKcs are directly associated with prognosis, neoplasm recurrence rates, and overall survival. Our results suggest that DNA-PKcs may serve as a therapeutic target for advanced malignancies.

Funder

Guangdong Basic and Applied Basic Research Foundation

National Natural Science Foundation of China

Publisher

SAGE Publications

Subject

Cancer Research,Oncology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/0300891620950472

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