Evaluation of Doxorubin Toxicity on Normal Hemopoietic Stem Cells

Abstract

The effect of administration of Doxorubicin (Dx) on the bone marrow CFUs, CFUe and CFUe has been evaluated in mice following injection of scalar single doses of the drug or during its repeated (3 times in 5 days) or prolonged (5 or 10 weeks) administration. In the first experiment the dose survival curves were exponential and the sensitivity of the 3 types of hemopoietic progenitors assayed was almost similar. During repeated or prolonged administration of Doxorubicin the CFUs appeared to be less affected by the drug than the committed progenitors.