Hepatic Arterial Infusion Chemotherapy in Sarcoma Liver Metastases: A Report of 6 Cases

Author:

Melichar Bohuslav12,Vobořil Zbyněk3,Nožička Jan4,Cerman Jaroslav25,Melicharová Karolina5,Mergancová Jindřiška3,Filip Stanislav12,Krajina Antonín6,Vobořil René3,Jandík Pavel3

Affiliation:

1. Department of Oncology & Radiotherapy, Charles University Medical School Teaching Hospital, Hradec Králové, Czech Republic

2. Medicine, Charles University Medical School Teaching Hospital, Hradec Králové, Czech Republic

3. Surgery, Charles University Medical School Teaching Hospital, Hradec Králové, Czech Republic

4. Pathology, Charles University Medical School Teaching Hospital, Hradec Králové, Czech Republic

5. Gerontology & Metabolic Care, Charles University Medical School Teaching Hospital, Hradec Králové, Czech Republic

6. Diagnostic Radiology, Charles University Medical School Teaching Hospital, Hradec Králové, Czech Republic

Abstract

Aims and background Liver metastases in patients with sarcoma are rare and associated with a poor prognosis. The experience with liver-directed therapies, eg hepatic arterial infusion, in these patients is limited. Methods Six patients with sarcoma metastatic to the liver (4 patients with gastrointestinal stromal tumors and 2 patients with leiomyosarcoma) were treated by hepatic arterial infusion in our center over a 12-year period. Since the experience was limited, a pooled analysis of reports with data on survival of 22 individual patients was performed. Results None of the 5 assessable patients responded to the therapy, and liver metastases progressed in all patients. The median survival was 20 months. In the pooled analysis, partial response was observed in 10 of 21 assessable patients (48%) and median survival was 20 months. The survival was significantly longer in responding patients compared to nonresponders (35 vs 14 months; logrank test, P= 0.009). Conclusions Hepatic arterial infusion has little efficacy in the treatment of sarcoma metastatic to the liver. More promising results have been reported for chemoembolization. The survival of responding patients seems to be better compared to non-responders.

Publisher

SAGE Publications

Subject

Cancer Research,Oncology,General Medicine

Cited by 7 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Surgical Management of Sarcoma Metastatic to Liver;Surgical Oncology Clinics of North America;2021-01

2. Un sarcome à cellules fusiformes du foie alimenté par l’artère mammaire interne;Journal de Radiologie Diagnostique et Interventionnelle;2015-09

3. A spindle cell sarcoma of liver supplied by internal mammary artery;Diagnostic and Interventional Imaging;2015-01

4. Isolated Hepatic Perfusion for the Treatment of Liver Metastases;Current Problems in Cancer;2012-03

5. Implanted Hepatic Arterial Infusion Pumps;The Cancer Journal;2010-03

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