Medical Treatment of Hepatocellular Carcinoma: Any Progress?

Author:

Colleoni Marco1,Gaion Fernando1,Liessi Guido2,Mastropasqua Giorgio3,Nelli Patrizia1,Manente Paolo1

Affiliation:

1. Department of Medical Oncology, Ospedale Civile, Castelfranco Veneto, Italy

2. Department of Radiology, Ospedale Civile, Castelfranco Veneto, Italy

3. Division of Medicine I, Ospedale Civile, Castelfranco Veneto, Italy

Abstract

Background Hepatocellular carcinoma (HCC) remains one of the most common neoplasms worldwide. Curative treatment options include liver transplantation or resection. Unfortunately, most patients still have unresectable or untransplantable HCC due to disease extension or comorbid factors and are therefore candidate only for palliative treatments. Methods In this review we have analyzed the different medical approaches employed in the treatment of HCC in an attempt to better define their roles. Results Palliative medical treatments including systemic chemotherapy, immunotherapy or hormonal manipulation rarely influence survival of the patients. Although a high response rate is often reported with new local therapies such as transcatheter arterial embolization, intraarterial chemotherapy or percutaneous ethanol injection, the real impact of these treatment modalities on patient survival remains to be determined. Conclusion One way to improve the diagnosis of HCC patients would be an appropriate approach to evaluate new drugs or treatment modalities. To answer all the open questions, further trials, possibly randomized, should be conducted on a substantial number of patients with homogeneous prognostic factors.

Publisher

SAGE Publications

Subject

Cancer Research,Oncology,General Medicine

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