Enhancement of Hematoporphyrin Derivative Uptake in Vitro and in Vivo by Tumor Cells in the Presence of Lanthanum

Abstract

Hematoporphyrin derivative is currently used as a photochemotherapeutic agent in the treatment of neoplasms. The uptake of hematoporphyrin derivative was determined in vitro and as a function of time with Ehrlich ascites cells in the presence of lanthanum and in vivo with VFM1 tumor-bearing mice pretreated by intratumoral injection of LaCl3. Our results indicate that the treatment with lanthanum increases the uptake of hematoporphyrin derivative by tumor cells.