Pathologic Assessment of Computerized Tomography Accuracy for the Evaluation of the Laryngeal Cartilaginous Frame Work in Laryngopharyngeal Carcinomas

Author:

Sulfaro Sandro1,Querin Francesco23,Barzan Luigi4,Lutman Mario23,Comoretto Roberto4,Volpe Rachele1,Carbone Antonino1

Affiliation:

1. Division of Pathology, Aviano, Italy

2. Centro di Riferimento Oncologico, Aviano, Italy

3. Associated Division of Radiology, Pordenone

4. Otolaryngology, of Pordenone General Hospital, Pordenone

Abstract

Sixty-six whole-organ sectioned laryngopharyngectomy specimens removed for cancer during a seven-year period were uniformly examined to determine the accuracy of preoperative high resolution computerized tomography (CT) for detection of cartilaginous involvement. Our results indicate that CT has a high overall specificity (88.2%) but a low sensitivity (47.1 %); we observed a high false-negative rate (26.5%) and a fairly low false-positive rate (5.9%). Massive cartilage destruction was easily assessed by CT, whereas both small macroscopic and microscopic neoplastic foci of cartilaginous invasion were missed on CT scans. Moreover, false-positive cases were mainly due to proximity of the tumor to the cartilage. Clinical implications of these results are discussed.

Publisher

SAGE Publications

Subject

Cancer Research,Oncology,General Medicine

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